Which condition leads to both bone fragility and impaired growth?

Osteogenesis imperfecta is indeed the condition that leads to both bone fragility and impaired growth. This genetic disorder, often referred to as "brittle bone disease," results from a defect in type I collagen, which is crucial for the strength and structure of bones. As a result, individuals with osteogenesis imperfecta experience frequent fractures and have bones that are weak and fragile. Additionally, the condition can also affect height and growth, particularly during childhood and adolescence, because the abnormal collagen impairs not only bone strength but also normal skeletal development.

Other conditions listed, while related to bone health, do not encompass both fragility and impaired growth in the same manner. Osteoporosis primarily affects bone density, leading to increased fragility, but it does not usually impede growth since it typically occurs later in life after growth plates have closed. Osteomalacia is characterized by softening of the bones due to vitamin D deficiency, which results in bone pain and deformity rather than direct growth impairment. Paget's disease results in abnormal bone remodeling and can lead to weakened bones, but it does not significantly impact growth in the way osteogenesis imperfecta does, as it typically occurs in adults. Thus, osteogenesis imperfecta stands out for its dual impact on